These data support an effect of IL-13 to decrease total and reduced GSH through high 15LO1, PEBP1, and GPX4 activity, which is partially compensated by (a) increased expression/activity of SLC7A11 to enhance new intracellular GSH production and (b) increased export of GSSG
NF-B, PI3K/AKT, and MAPK pathways collectively regulate intracellular GSH and antioxidant capacity, helping tumors evade ROS-dependent therapies
Zhou, H.M., Li, D.C., Wang, Y.Y., Zhu, H., Su, Y.Q., and Mao, Y., Fish Shellfish Immun
Therefore, KCCYSL-based peptides can be used for imaging of HER2-positive tumors with k d of 295 nM [61]
G., Rosania, G
Stable gastric pentadecapeptide BPC 157, in clinical trials as a therapy for inflammatory bowel disease (PL14736), is effective in the healing of colocutaneous fistulas in rats: role of the nitric oxide-system